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Molecular clocks have been discovered in immune cells including macrophages/monocytes, T cells, NK cells, dendritic cells, and B cells (Ella et al., 2016), along with a circadian regulation in recruitment and infiltration of immune cells including neutrophils, monocytes/macrophages, and T cells, which infiltrate the injury site after the integrity of the BBB is compromised (Scheiermann et al., 2013)

Of note, the Institute of Medicine (2006) stated that dietary arginine was not required by healthy adults because arginine is synthesized via the hepatic urea cycle